Bo Shen, Ph.D.
Assistant Investigator, NIBS, Beijing
Email: shenbo@wanzixs.com
Home page: http://www.shenlaboratory.com/
2015 - Ph.D. in Pharmacology, University of Illinois College of Medicine, Chicago, Illinois, USA (Lab of Dr. Xiaoping Du)
2008 - B.S., College of Science, National University of Singapore, Singapore
2021 - Assistant Investigator, National Institute of Biological Sciences, Beijing
2015-2021 - Postdoctoral Research Fellow, Children, Children's Medical Center Research Institute at UT Southwestern, Dallas, Texas, USA (Lab of Dr. Sean Morrison)
ECM (Extra云顶集团(中国)ular Matrix) proteins have many functions beyond providing structural support. We will work on ECM proteins in the bone marrow microenvironment, aiming to characterize and discover new growth factor activities from ECM proteins in the context of stem 云顶集团(中国) functions. In particular, we are interested in finding novel ECM proteins as regulators of hematopoietic stem 云顶集团(中国)s and skeletal stem 云顶集团(中国)s. These findings will hopefully have therapeutic potentials in regenerative medicine, in the context of blood and bone diseases.
Research Articles:
1. Shen B, Tasdogan A, Ubellacker JM, Zhang J, Nosyreva ED, Du L, Murphy MM, Hu S, Yi Y, Kara N, Liu X, Guela S, Jia Y, Ramesh V, Embree C, Mitchell EC, Zhao YC, Ju LA, Zhao H, Crane GM, Zhao Z, Syeda R, Morrison SJ. A mechanosensitive peri-arteriolar niche for osteogenesis and lymphopoiesis. Nature, 591(7850):438 (2021). PMID: 33627868.
2. Zhang J, Cohen A, Shen B, Du L, Tasdogan A, Zhao Z, Shane EJ, Morrison SJ. Parathyroid hormone promotes osteogenesis partly by promoting Osteolectin expression. Proc Natl Acad Sci, 118 (25) e2026176118 (2021). PMID: 34140410
3. Wei H, Xu Y, Wang Y, Xu L, Mo C, Li L, Shen B, Sun Y, Cheng P, Yang L, Pang Y, Qin A, Cao Y, Morrison SJ, Yue R. Identification of Fibroblast Activation Protein as an Osteogenic Suppressor and Anti-osteoporosis Drug Target. 云顶集团(中国) Reports 33(2):108252 (2020). PMID: 33053358.
4. Men Y, Wang Y, Yi Y, Jing D, Luo W, Chai Y, Ge WP, Shen B, Stenberg W, Feng JQ, Zhao H. Gli1+ periodontium stem 云顶集团(中国)s are regulated by osteocytes and occlusal force. Developmental 云顶集团(中国). 54(5):639-654 (2020). PMID: 32652075.
5. Ubellacker JM, Tasdogan A, Ramesh V, Shen B, Mitchell, EC, Martin MS, Gu Z, McCormick ML, Durham AB, Spitz DR, Zhao Z, Mathews TP, Morrison SJ. Lymph protects metastasizing melanoma 云顶集团(中国)s from ferroptosis. Nature. 585, 113–118 (2020). PMID: 32814895.
6. Gao X, Zhang Z, Mashimo T, Shen B, Nyagilo J, Wang H, Wang Y, Liu Z, Mulgaonkar A, Hu XL, Piccirillo SGM, Eskiocak U, Davé DP, Qin S, Yang Y, Sun X, Fu YX, Zong H, Sun W, Bachoo RM, Ge WP. Gliomas Interact with Non-glioma Brain 云顶集团(中国)s via Extra云顶集团(中国)ular Vesicles. 云顶集团(中国) Rep, 30(8):2489-2500 (2020). PMID: 32101730.
7. Tasdogan A, Faubert B, Ramesh V, Ubellacker JM, Shen B, Solmonson A, Murphy MM, Gu Z, Gu W, Martin M, Kasitinon SY, Vandergriff T, Mathews TP, Zhao Z, Schadendorf D, DeBerardinis RJ*, Morrison SJ*. Metabolic heterogeneity confers differences in melanoma metastatic potential. Nature, 577(7788):115-120, *co-corresponding authors (2020). PMID: 31853067.
8. Shen B, Vardy K, Hughes P, Tasdogan A, Zhao Z, Yue R, Crane G, Morrison SJ. Integrin alpha11 is an Osteolectin receptor and is required for the maintenance of adult skeletal bone mass. eLife. 8:e42274 (2019). PMID: 30632962.
9. Yue R, Shen B, Morrison SJ. Clec11a is an osteogenic factor that promotes the maintenance of the adult skeleton. eLife, 5:e18782 (2016). PMID: 27976999.
10. Delaney MK, Kim K, Esteves B, Xu Z, Stojanovic-Terpo A, Shen B, Ushio-Fukai M, Cho J, Du X. Differential Roles of the NADPH-Oxidase 1 and 2 in Platelet Activation and Thrombosis. Arteriosclerosis, Thrombosis, and Vascular Biology, 36(5):846-854 (2016). PMID: 26988594.
11. Esteves B, Kim K, Delaney MK, Stojanovic-Terpo A, Shen B, Ruan C, Cho J, Ruggeri ZM, Du X. Signaling-Mediated Cooperativity between Glycoprotein Ib-IX and Protease-Activated Receptors in Thrombin-Induced Platelet Activation. Blood, 127(5):626-636 (2016). PMID: 26585954.
12. Shen B, Esteves B, Kreutz B, Xu Z, Karginov A, Bai Y, Qian F, Norifumi U, Mosher DF, Du X. The interaction of Galpha13 with integrin beta1 mediates 云顶集团(中国) migration by dynamic regulation of RhoA. Mol Biol 云顶集团(中国), 26(20):3658-3670 (2015). PMID: 26310447.
13. Esteves B, Shen B, Du X. Targeting Integrin and Integrin Signaling in Treating Thrombosis. Arterioscler Thromb Vasc Biol. 35(1):24-29 (2015). PMID: 25256236.
14. Delaney MK, Liu L, Kim K, Shen B, Stojanovic-Terpo A, Zheng Y, Cho J, Du X. Agonist-induced platelet procoagulant activity requires shear and a Rac1-dependent signaling mechanism. Blood, 124(12):1957-1967 (2014). PMID: 25079357.
15. Shen B, Zhao X, O’Brien KA, Stojanovic-Terpo A, Delaney MK, Kim K, Cho J, Lam SCT, Du X. A mechanism for the directional switch of integrin signaling and selective inhibition of outside-in signaling as a new anti-thrombotic strategy. Nature, 503(7474):131-135 (2013). PMID: 24162846.
16. Shen B, Delaney MK, Du X. Inside-out, outside-in, and inside-outside-in: G protein signaling in integrin-mediated 云顶集团(中国) adhesion, spreading, and retraction. Curr Opin 云顶集团(中国) Biol, 24(5):600-606 (2012). PMID: 22980731.
17. Gong H, Shen B, Flevaris P, Chow C, Lam SCT, Voyno-Yasenetskaya TA, Kozasa T, Du X. G protein subunit Galpha13 binds to integrin alphaIIbbeta3 and mediates integrin "outside-in" signaling. Science, 327(5963):340-343 (2010). PMID: 20075254.
Review Articles:
18. Stefano C#, Shen B#, Morrison SJ. Niches that regulate stem 云顶集团(中国)s and hematopoiesis in adult bone marrow. Developmental 云顶集团(中国), 2021, online now. #: contributed equally.
19. Esteves B, Shen B, Du X. Targeting Integrin and Integrin Signaling in Treating Thrombosis. Arterioscler Thromb Vasc Biol. 35(1):24-29 (2015). PMID: 25256236.
20. Shen B, Delaney MK, Du X. Inside-out, outside-in, and inside-outside-in: G protein signaling in integrin-mediated 云顶集团(中国) adhesion, spreading, and retraction. Curr Opin 云顶集团(中国) Biol, 24(5):600-606 (2012). PMID: 22980731.
