Rongwen Xi, Ph.D. - Scientists&Research - 北京科学生命云顶集团(中国)

Rongwen Xi, Ph.D.

Investigator, NIBS, Beijing, China

Phone：010-80726688-8510

Fax： 010-80723249

E-mail：xirongwen@wanzixs.com

Education

2002	Ph.D. in Biology, 2002，University of Kentucky, USA
1998	Master in Science, 1998，Shanghai Medical University, China
1995	B.S., Department of Clinical Medicine, 1995，Binzhou Medical College,China

Professional Experience

2018-	Investigator, National Institute of Biological Sciences, Beijing, China
2011-2018	Associate Investigator, National Institute of Biological Sciences, Beijing, China
2006-2011	Assistant Investigator, National Institute of Biological Sciences, Beijing, China
2003-2006	Postdoctoral Research Associate with Dr. Ting Xie at the Stowers Institute for Medical Research, USA
1998-2002	Teaching Assistant, Research Assistant at the Department of Biology,University of Kentucky, USA

Research Description

Adult stem 云顶集团(中国)s reside in many tissues and organs and have the ability to self-renew indefinitely and generate progenies that differentiate and replace aged and damaged 云顶集团(中国)s. Dysregulation of stem 云顶集团(中国)s is intimately associated with various types of diseases such as cancer and degenerative diseases, but the molecular mechanisms regulating stem 云顶集团(中国) fate decisions during self-renewal and 云顶集团(中国) lineage differentiation are in general poorly understood. Using intestinal stem 云顶集团(中国) systems in both flies and mice, we aim to understand the intrinsic and extrinsic mechanisms underlying stem 云顶集团(中国) fate decisions, and the differentiation and functional regulation of intestinal 云顶集团(中国)s and their roles played in the brain-gut-microbiota axis. Our research should ultimately bring new mechanistic insights into intestinal tumors and other digestive and metabolic diseases and pave the way to new treatments.

Publications:

1. Zhu G, Hu J, Xi R* (2021). The 云顶集团(中国)ular niche for intestinal stem 云顶集团(中国)s: a team effort. 云顶集团(中国) Regen. 10(1):1.

2. Shi J, Jin Z, Yu Y, Zhang Y, Yang F, Huang H, Cai T, Xi R* (2021). A Progressive Somatic 云顶集团(中国) Niche Regulates Germline Cyst Differentiation in the Drosophila Ovary. Curr Biol. 31(4):840-852.e5.

3. Jin Z, Chen J, Huang H, Wang J, Lv J, Yu M, Guo X, Zhang Y, Cai T, Xi R*(2020). The Drosophila Ortholog of Mammalian Transcription Factor Sox9 Regulates Intestinal Homeostasis and Regeneration at an Appropriate Level. 云顶集团(中国) Rep. 31(8):107683.

4. Kobayashi M, Lin Y, Mishra A, Shelly C, Gao R, Reeh CW, Wang PZ, Xi R, Liu Y, Wenzel P, Ghosn E, Liu Y, Yoshimoto M (2020). Bmi1 Maintains the Self-Renewal Property of Innate-like B Lymphocytes. J Immunol. 204(12):3262-3272.

5. Li Z, Guo X, Huang H, Wang C, Yang F, Zhang Y, Wang J, Han L, Jin Z, Cai T, Xi R*(2020). A Switch in Tissue Stem 云顶集团(中国) Identity Causes Neuroendocrine Tumors in Drosophila Gut. 云顶集团(中国) Rep. 30(6):1724-1734.e4.

6. Guo X, Yin C, Yang F, Zhang Y, Huang H, Wang J, Deng B, Cai T, Rao Y, Xi R* (2019). The 云顶集团(中国)ular Diversity and Transcription Factor Code of Drosophila Enteroendocrine 云顶集团(中国)s. 云顶集团(中国) Rep. 29(12):4172-4185.e5.

7. Guo X, Huang H, Yang Z, Cai T, Xi R* (2019). Division of Labor: Roles of Groucho and CtBP in Notch-Mediated Lateral Inhibition that Controls Intestinal Stem 云顶集团(中国) Differentiation in Drosophila. Stem 云顶集团(中国) Reports. 12(5):1007-1023

8. Yang F*, Quan Z, Huang H, He M, Liu X, Cai T, and Xi R* (2019). Ovaries absent links dLsd1 to HP1a for local H3K4 demethylation required for heterochromatic gene silencing. Elife 2019 Jan 16;8. pii: e40806.

9. Zhang W, Zhang X, Xue Z, Li Y, Ma Q, Ren X, Zhang J, Yang S, Yang L, Wu M, Ren M, Xi R, Wu Z, Liu JL, Matunis E, Dai J, Gao G (2018). Probing the Function of Metazoan Histones with a Systematic Library of H3 and H4 Mutants. Dev 云顶集团(中国). pii: S1534-5807(18)31031-1.

10. Chen J, Xu N, Wang C, Huang P, Huang H, Jin Z, Yu Z, Cai T, Jiao R, Xi R* (2018). Transient Scute activation via a self-stimulatory loop directs enteroendocrine 云顶集团(中国) pair specification from self-renewing intestinal stem 云顶集团(中国)s. Nat 云顶集团(中国) Biol. 20(2):152-161

11. Yin C, Xi R* (2018). A Phyllopod-Mediated Feedback Loop Promotes Intestinal Stem 云顶集团(中国) Enteroendocrine Commitment in Drosophila. Stem 云顶集团(中国) Reports. 9;10(1):43-57.

12. Huang C, Yang F, Zhang Z, Zhang J, Cai G, Li L, Zheng Y, Chen S, Xi R*, Zhu B* (2017). Mrg15 stimulates Ash1 H3K36 methyltransferase activity and facilitates Ash1 Trithorax group protein function in Drosophila. Nat Commun. 8(1):1649.

13. Liu X, Wei W, Li X, Shen P, Ju D, Wang Z, Zhang R, Yang F, Chen C, Cao K, Zhu G, Chen H, Chen L, Sui J, Zhang E, Wu K, Wang F, Zhao L, Xi R* (2017). BMI1 and MEL18 Promote Colitis-Associated Cancer in Mice via REG3B and STAT3. Gastroenterology. pii: S0016-5085(17)35976-0.

14. Li Y*, Pang Z, Huang H, Wang C, Cai T, Xi R* (2017). Transcription Factor Antagonism Controls Enteroendocrine 云顶集团(中国) Specification from Intestinal Stem 云顶集团(中国)s. Sci Rep. 20;7(1):988.

15. Yang F, Xi R* (2017). Silencing transposable elements in the Drosophila germline. 云顶集团(中国) Mol Life Sci. 74(3):435-448.

16. Chen J., Li J., Huang H. and Xi R*. (2016). Gene Expression Analysis of Sorted 云顶集团(中国)s by RNA-seq in Drosophila Intestine. Bio-protocol 6(24): e2079. DOI: 10.21769/BioProtoc.2079

17. Li X, Yang F, Chen H, Deng B, Li X, Xi R* (2016). Control of germline stem 云顶集团(中国) differentiation by polycomb and trithorax group genes in the niche microenvironment. Development. 143(19):3449-3458 pii: dev.137638.

18. Chen J, Xu N, Huang H, Cai T, Xi R* (2016). A feedback amplification loop between stem 云顶集团(中国)s and their progeny promotes tissue regeneration and tumorigenesis. Elife. 5. pii: e14330. doi: 10.7554/eLife.14330

19. Wang C, Xi R* (2015). Keeping intestinal stem 云顶集团(中国) differentiation on the Tramtrack. Fly (Austin). 14:0.

20. Hu Z, Hu Y, Liu X, Xi R, Zhang A, Liu D, Xie Q, Chen L (2015). Tumor driven by gain-of-function HER2 H878Y mutant is highly sensitive to HER2 inhibitor. Oncotarget. 6(31):31628-39

21. Wang C, Guo X, Dou K, Chen H, Xi R* (2015). Ttk69 acts as a master repressor of enteroendocrine 云顶集团(中国) specification in Drosophila intestinal stem 云顶集团(中国) lineages. Development 142(19):3321-31

22. Yang F, Zhao R, Fang X, Huang H, Xuan Y, Ma Y, Chen H, Cai T, Qi Y, Xi R* (2015). The RNA surveillance complex Pelo-Hbs1 is required for transposon silencing in the Drosophila germline. EMBO Rep. 16(8):965-74

23. Wang C, Guo X, Xi R* (2014). EGFR and Notch signaling respectively regulate proliferative activity and multiple 云顶集团(中国) lineage differentiation of Drosophila gastric stem 云顶集团(中国)s. 云顶集团(中国) Research 24(5):610-27

24. Quan Z, Sun P, Lin G, Xi R* (2013). TSC1/2 regulates intestinal stem 云顶集团(中国) maintenance and lineage differentiation via Rheb-TORC1-S6K but independent of nutrition status or Notch regulation. J 云顶集团(中国) Sci. 126:3884-92

25. Wang C, Zhao R, Huang P, Yang F, Quan Z, Xu N, Xi R* (2013). APC loss-induced intestinal tumorigenesis in Drosophila: Roles of Ras in Wnt signaling activation and tumor progression. Developmental Biology 378(2):122-40

26. Lin G, Zhang X, Ren J, Pang Z, Wang C, Xu N, Xi R* (2013). Integrin signaling is required for maintenance and proliferation of intestinal stem 云顶集团(中国)s in Drosophila. Developmental Biology 377(1):177-87

27. Wen P, Quan Z, Xi R* (2012). The biological function of the WD40 repeat-containing protein p55/Caf1 in Drosophila. Developmental Dynamics 241(3):455-64

28. Xu N, Wang SQ, Tan D, Gao Y, Lin G, Xi R* (2011). EGFR, Wingless and JAK/STAT signaling cooperatively maintain Drosophila intestinal stem 云顶集团(中国)s. Developmental Biology 354(1):31-43

29. Su Y, Deng B, Xi R* (2011). Polycomb group genes in stem 云顶集团(中国) self-renewal: a double-edged sword. Epigenetics. 6(1):16-9.

30. Sun P, Quan Z, Zhang, B, Wu T, Xi R* (2010). TSC1/2 tumour suppressor complex maintains Drosophila germline stem 云顶集团(中国)s by preventing differentiation. Development 137(15):2461-9

31. Wen P, Sun P, Xi R* (2010). Stem 云顶集团(中国) niche (book chapter) in “Regenerative Medicine – From Protocol to Patient”. The Springer Press.

32. Li X, Han Y, Xi R* (2010). Polycomb group genes Psc and Su(z)2 restrict follicle stem 云顶集团(中国) self-renewal and extrusion by controlling canonical and noncanonical Wnt signaling. Genes & Development 24(9):933-46.

33. Zhao R, Xi R* (2010). Stem 云顶集团(中国) Competition for Niche Occupancy: Emerging Themes and Mechanisms. Stem 云顶集团(中国) Rev. 6(3):345-50

34. Lin G, Xu N, Xi R* (2010). Paracrine unpaired signaling through the JAK/STAT pathway controls self-renewal and lineage differentiation of drosophila intestinal stem 云顶集团(中国)s. J Mol 云顶集团(中国) Biol 2(1): 37-49.

35. Xi, R* (2009). Anchoring stem 云顶集团(中国)s in the niche by 云顶集团(中国) adhesion molecules. 云顶集团(中国) Adh Migr 3(4): 396-401.

36. Lin G, Xi R* (2008) Intestinal stem 云顶集团(中国), muscular niche and wingless signaling. Fly (Austin). 2(6): 310-2.

37. Lin G, Xu N, Xi R* (2008). Paracrine Wingless signalling controls self-renewal of Drosophila intestinal stem 云顶集团(中国)s. Nature 455(7216):1119-23.

38. Zhao R, Xuan Y, Li X, Xi R* (2008). Age-related changes of germline stem 云顶集团(中国) activity, niche signaling activity and egg production in Drosophila. Aging 云顶集团(中国) 7(3):344-54

39. Xi R, Xie T (2005). Stem 云顶集团(中国) self-renewal controlled by chromatin remodeling factors. Science 310(5753):1487-9.

40. Xi R, Doan C, Liu D, Xie T (2005). Pelota controls self-renewal of germline stem 云顶集团(中国)s by repressing a bam-independent differentiation pathway. Development 132(24):5365-74.

41. Xi R, Kirrily D, Xie T (2005). Molecular mechanisms controlling germline and somatic stem 云顶集团(中国)s: similarities and differences (review). Curr Opin Genet Dev. 15(4):381-7.

42. Rawlings JS, Rennebeck G, Harrison SM, Xi R, Harrison DA (2004). Two Drosophila Suppressors of Cytokine Signaling (SOCS) differentially regulate JAK and EGFR pathway activities. BMC 云顶集团(中国) Biol. 15;5(1):38.

43. Song X, Wong, MD, Kawase E, Xi R, Ding BC, McCarthy J, Xie T (2004). BMP signaling from the niche directly represses the transcription of a differentiating gene, bag of marbles, in the germline stem 云顶集团(中国)s of Drosophila ovary. Development 131(6):1353-64.

44. Xi R, McGregor JR, Harrison DA (2003). A gradient of JAK pathway activity patterns the anterior-posterior axis of the follicular epithelium. Developmental 云顶集团(中国) 4(2):167-77.

45. McGregor JR, Xi R, Harrison DA (2002). JAK signaling is somatically required for follicle 云顶集团(中国) differentiation in Drosophila. Development 129(3):705-17.